Thanmathra (2005)

Ramesan Nair (Mohanlal) is a Kerala government secretariat employee, cocooned in his own small and happy world. An honest and sincere man, Ramesan's family consists of his loving wife Lekha (Meera Vasudevan), son Manu (Arjun Lal) who is a plus-two student, and daughter Manju (Baby Niranjana), a primary school student. His biggest ambition is to see that his son gets into the IAS (Indian Administrative Service), something he himself had failed to achieve despite being a brilliant student. Manu is a very loving son and an intelligent student who shares a strong emotional bond with his father. All in all, they form the very picture of loving family, with a bright future.[3]
However, fate has other ideas. Ramesan starts to develop problems with his memory. What starts as commonplace omissions and absentmindedness, quickly grows into handicapping cognitive and behavioral impairments.
The first time we notice this is when Ramesan misplaces a very important office file at his home, inside the refrigerator. One day he arrives in office after buying a bag of vegetables and starts behaving as if he had reached home after his office hours. He begins acting strangely in the office, as if he has lost his sense of time and place. He is taken to the doctor by his family and close friend, Joseph (Jagathy Sreekumar).
In the hospital, Ramesan is diagnosed with Familial Alzheimer's disease, a disease which causes a gradual loss of memory and cognitive abilities. The news comes as a grave shock for the happy family and turns their world upside down. The family is devastated by the sad news, but tries to adjust to the situation with a lot of determination underscored by strong emotional bonds. How they cope up with the trauma, insecurity and uncertainty caused by Ramesan's plight, forms the gist of the movie.